NCLEX Insulin Pharmacology Reference
Understanding insulin pharmacokinetic profiles is critical for passing the NCLEX, as nursing interventions and hypoglycemia monitoring depend entirely on these timelines.
Rapid-Acting (Lispro, Aspart, Glulisine): Onset is 15 to 30 minutes, peaks within 1 to 2 hours, and lasts 3 to 6 hours. Nursing Tip: Ensure the patient’s meal tray is in front of them before injecting.
Short-Acting (Regular): Onset is 30 minutes to 1 hour, peaks within 2 to 4 hours, and lasts 3 to 6 hours. Nursing Tip: This is the only insulin type that can be given intravenously (IV).
Intermediate-Acting (NPH): Onset is 2 to 4 hours, peaks within 8 to 10 hours, and lasts 10 to 18 hours. Nursing Tip: NPH is a cloudy suspension that must be rolled gently, never shaken.
Long-Acting (Gargine, Detemir): Onset is 1 to 2 hours, has no peak action, and lasts 19 to 24 hours. Nursing Tip: Provides a stable basal rate and can never be mixed in the same syringe with other insulins.
A handy insulin cheat sheet for studying and clinical.
