Factors Affecting Prognosis for Clients with Malignant Melanoma: An NCLEX Practice Quiz Factors Affecting Prognosis for Clients with Malignant Melanoma: An NCLEX Practice Quiz What factors influence the prognosis for a client with malignant melanoma?*1. The amount of ulceration of the lesion.2. The age of the client.3. The location of the lesion on the body.4. The thickness of the lesion.